Fri Oct 21 2022

86 articles - From Friday Oct 14 2022 to Friday Oct 21 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Ann Intern Med

Effectiveness of Opioid Analgesic Medicines Prescribed in or at Discharge From Emergency Departments for Musculoskeletal Pain : A Systematic Review and Meta-analysis.

The risk-benefit balance of opioids versus placebo, paracetamol, NSAIDs, and local or systemic anesthetics is uncertain. Opioids may have equivalent pain outcomes compared with NSAIDs, but evidence on comparisons of harms is very uncertain and heterogeneous. Although factors such as route of administration or dosage may explain some heterogeneity, more work is needed to identify which subgroups will have a more favorable benefit-risk balance for one analgesic over another. Longer-term pain management once dose thresholds are reached is also uncertain. Primary funding source None. (PROSPERO CRD42021275293).

Pubmed   Journal   ReadQx 

The Impact of the COVID-19 Pandemic and Associated Control Measures on the Mental Health of the General Population : A Systematic Review and Dose-Response Meta-analysis.

Although an initial increase in average symptoms of depression and anxiety and an association between higher numbers of reported cases and more stringent measures were found, changes in mental health symptoms varied substantially across studies after the first 2 months of the pandemic. This suggests that different populations responded differently to the psychological stress generated by the pandemic and its containment measures. Primary funding source Swiss National Science Foundation. (PROSPERO CRD42020180049).

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Apixaban Versus Rivaroxaban in Patients With Atrial Fibrillation and Valvular Heart Disease : A Population-Based Study.

In this study of patients with AF and VHD, patients receiving apixaban had a lower risk for ischemic stroke or systemic embolism and for bleeding when compared with those receiving rivaroxaban. Primary funding source National Institutes of Health.

Pubmed   Journal   ReadQx 

Lancet

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial.

These findings might also have implications for antisepsis of other traumatic wounds. Funding US Department of Defense, Canadian Institutes of Health Research, McMaster University Surgical Associates, PSI Foundation.

Pubmed   Journal   ReadQx 

Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial.

Patients can be advised that they can take their regular antihypertensive medications at a convenient time that minimises any undesirable effects. Funding British Heart Foundation.

Pubmed   Journal   ReadQx 

Comparing dedicated and designated approaches to integrating task-shared psychological interventions into chronic disease care in South Africa: a three-arm, cluster randomised, multicentre, open-label trial.

This trial extends evidence for CHW-delivered psychological interventions, offering insights into how different delivery approaches affect patient outcomes. Funding British Medical Research Council, Wellcome Trust, UK Department for International Development, the Economic and Social Research Council, and the Global Challenges Research Fund.

Pubmed   Journal   ReadQx 

Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales.

Interpretation Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial vaccine booster and should, therefore, be prioritised for additional boosters, including novel optimised versions, and the increasing array of COVID-19 therapeutics. Funding National Core Studies-Immunity, UK Research and Innovation (Medical Research Council), Health Data Research UK, the Scottish Government, and the University of Edinburgh.

Pubmed   Journal   ReadQx   PMC

Sustained detection of type 2 poliovirus in London sewage between February and July, 2022, by enhanced environmental surveillance.

Whole-genome sequences generated through nanopore sequencing established linkage of isolates and confirmed transmission of a unique recombinant poliovirus lineage that has now been detected in Israel and the USA. Funding Medicines and Healthcare products Regulatory Agency, UK Health Security Agency, Bill & Melinda Gates Foundation, and National Institute for Health Research Medical Research Council.

Pubmed   Journal   ReadQx 

N Engl J Med

Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation.

These data support an autosomal dominant mitochondrial uncoupling syndrome with hypermetabolism. (Funded by the National Institutes of Health.).

Pubmed   Journal   ReadQx 

Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age.

Two 25-µg doses of the mRNA-1273 vaccine were found to be safe in children 6 months to 5 years of age and elicited immune responses that were noninferior to those in young adults. (Funded by the Biomedical Advanced Research and Development Authority and National Institute of Allergy and Infectious Diseases; KidCOVE ClinicalTrials.gov number, NCT04796896.).

Pubmed   Journal   ReadQx 

Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion.

In a trial involving Chinese patients with basilar-artery occlusion, approximately one third of whom received intravenous thrombolysis, endovascular thrombectomy within 12 hours after stroke onset led to better functional outcomes at 90 days than best medical care but was associated with procedural complications and intracerebral hemorrhage. (Funded by the Program for Innovative Research Team of the First Affiliated Hospital of USTC and others; ATTENTION ClinicalTrials.gov number, NCT04751708.).

Pubmed   Journal   ReadQx 

Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion.

Among patients with stroke due to basilar-artery occlusion who presented 6 to 24 hours after symptom onset, thrombectomy led to a higher percentage with good functional status at 90 days than medical therapy but was associated with procedural complications and more cerebral hemorrhages. (Funded by the Chinese National Ministry of Science and Technology; BAOCHE ClinicalTrials.gov number, NCT02737189.).

Pubmed   Journal   ReadQx 

Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo.

In two phase 3 trials, application of ruxolitinib cream resulted in greater repigmentation of vitiligo lesions than vehicle control through 52 weeks, but it was associated with acne and pruritus at the application site. Larger and longer trials are required to determine the effect and safety of ruxolitinib cream in patients with vitiligo. (Funded by Incyte; TRuE-V1 and TRuE-V2 ClinicalTrials.gov numbers, NCT04052425 and NCT04057573.).

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Offline: The embodiment of political failure.

Pubmed   Journal   ReadQx 

UK health needs a plan, not ideology.

Pubmed   Journal   ReadQx 

N Engl J Med

Audio Interview: Covid-19: Where Are We Heading?

Pubmed   Journal   ReadQx 

Audio Interview: Developing New Covid-19 Vaccines.

Pubmed   Journal   ReadQx 

Favorable Outcomes in Endovascular Therapy for Basilar-Artery Occlusion.

Pubmed   Journal   ReadQx 

John Jarcho, M.D., Beloved Colleague and Friend, 1957-2022.

Pubmed   Journal   ReadQx 

New Hope for Patients with Vitiligo.

Pubmed   Journal   ReadQx 

Oxygenation and Blood-Pressure Targets in the ICU after Cardiac Arrest - One Step Forward.

Pubmed   Journal   ReadQx 


Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals for Educators - October 2022.

Pubmed   Journal   ReadQx 

Annals for Hospitalists - October 2022.

Pubmed   Journal   ReadQx 

Annals Video Summary - Effectiveness of Opioid Analgesic Medicines Prescribed in or at Discharge From Emergency Departments for Musculoskeletal Pain.

Pubmed   Journal   ReadQx 

Comparison of SARS-CoV-2 Reverse Transcriptase Polymerase Chain Reaction and BinaxNOW Rapid Antigen Tests at a Community Site During an Omicron Surge.

Pubmed   Journal   ReadQx 

Comparison of SARS-CoV-2 Reverse Transcriptase Polymerase Chain Reaction and BinaxNOW Rapid Antigen Tests at a Community Site During an Omicron Surge.

Pubmed   Journal   ReadQx 

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Pubmed   Journal   ReadQx 

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Pubmed   Journal   ReadQx 

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Pubmed   Journal   ReadQx 

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Pubmed   Journal   ReadQx 

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

Pubmed   Journal   ReadQx 

I Talk to My Cyst.

Pubmed   Journal   ReadQx 

Monkeypox: Challenging Clinical Questions.

Pubmed   Journal   ReadQx 

Prevalence and Correlates of Patient Rationing of Insulin in the United States: A National Survey.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals Consult Guys - Perioperative Care of Patients With Hypertension.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals for Hospitalists Inpatient Notes - Taking Ownership of the Care of Patients With Opioid Use Disorder in the Hospital.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals On Call - Estimated Glomerular Filtration Rate Variability.

Pubmed   Journal   ReadQx 

Lancet

"The fear never goes away": women's health in Iran.

Pubmed   Journal   ReadQx 

Best time for administration of antihypertensive medications: morning or evening?

Pubmed   Journal   ReadQx 

Dedicated and designated approaches to task-shared psychological interventions.

Pubmed   Journal   ReadQx 

Detection of poliovirus in London highlights the value of sewage surveillance.

Pubmed   Journal   ReadQx 

Electron microscopy images of monkeypox virus infection in 24-year-old man.

Pubmed   Journal   ReadQx 

European Health Union a step closer.

Pubmed   Journal   ReadQx 

Pääbo wins Nobel Prize for work on human evolution.

Pubmed   Journal   ReadQx 

Pain, popping, and episodic locking of the knee: osteochondromatosis.

Pubmed   Journal   ReadQx 

Patients with open fractures: an understudied population in surgical site preparation.

Pubmed   Journal   ReadQx 

Paul Daryll Wilkinson.

Pubmed   Journal   ReadQx 

Prioritisation of COVID-19 boosters in the omicron era.

Pubmed   Journal   ReadQx   PMC

The polypill: from concept and evidence to implementation.

Pubmed   Journal   ReadQx 

The scientific communication ecosystem: the responsibility of investigators.

Pubmed   Journal   ReadQx 

UK report underscores potential of e-cigarettes to reduce smoking harms.

Pubmed   Journal   ReadQx 

N Engl J Med

Atrial Fibrillation - What Is It and How Is It Treated?

Pubmed   Journal   ReadQx 

Case 31-2022: A 72-Year-Old Man with Heartburn, Nausea, and Inability to Eat.

Pubmed   Journal   ReadQx 

Case 32-2022: A 76-Year-Old Man with Postoperative Cardiogenic Shock and Diffuse Rash.

Pubmed   Journal   ReadQx 

Chronic Arsenic Poisoning.

Pubmed   Journal   ReadQx 

COP27 Climate Change Conference - Urgent Action Needed for Africa and the World.

Pubmed   Journal   ReadQx 

Diversity in Clinical Trials - Next Steps.

Pubmed   Journal   ReadQx 

Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis.

Pubmed   Journal   ReadQx 

Impending Relief for Medicare Beneficiaries - The Inflation Reduction Act.

Pubmed   Journal   ReadQx 

Migraine - Treatment and Preventive Therapies.

Pubmed   Journal   ReadQx 

Tinea Nigra.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Ann Intern Med

Effects of State Opioid Prescribing Laws on Use of Opioid and Other Pain Treatments Among Commercially Insured U.S. Adults.

Pubmed   Journal   ReadQx 

Lancet

Algorithm-based care after pancreatic resection - Authors' reply.

Pubmed   Journal   ReadQx 

Algorithm-based care after pancreatic resection.

Pubmed   Journal   ReadQx 

Algorithm-based care after pancreatic resection.

Pubmed   Journal   ReadQx 

Reconsidering the COVID-19 vaccine strategy in West and Central Africa.

Pubmed   Journal   ReadQx   PMC

The monkeypox case definition in the UK is broad - Authors' reply.

Pubmed   Journal   ReadQx 

The monkeypox case definition in the UK is broad.

Pubmed   Journal   ReadQx 

N Engl J Med

Anti-BDCA2 Antibody for Cutaneous Lupus Erythematosus.

Pubmed   Journal   ReadQx 

Anti-BDCA2 Antibody for Cutaneous Lupus Erythematosus. Reply.

Pubmed   Journal   ReadQx 

Brentuximab Vedotin in Advanced Hodgkin's Lymphoma.

Pubmed   Journal   ReadQx 

Brentuximab Vedotin in Advanced Hodgkin's Lymphoma. Reply.

Pubmed   Journal   ReadQx 

Case 23-2022: A 49-Year-Old Man with Hypoglycemia.

Pubmed   Journal   ReadQx 

Incidence of Chronic Kidney Disease among Adults with Diabetes, 2015-2020.

Pubmed   Journal   ReadQx 

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents.

Pubmed   Journal   ReadQx 

Neutralization Escape by SARS-CoV-2 Omicron Subvariant BA.4.6.

Pubmed   Journal   ReadQx 

Once-Weekly Dulaglutide for Treatment of Youths with Type 2 Diabetes.

Pubmed   Journal   ReadQx 

Once-Weekly Dulaglutide for Treatment of Youths with Type 2 Diabetes. Reply.

Pubmed   Journal   ReadQx 

Pembrolizumab in Triple-Negative Breast Cancer.

Pubmed   Journal   ReadQx 

Pembrolizumab in Triple-Negative Breast Cancer.

Pubmed   Journal   ReadQx 

Pembrolizumab in Triple-Negative Breast Cancer. Reply.

Pubmed   Journal   ReadQx 

Tirzepatide Once Weekly for the Treatment of Obesity.

Pubmed   Journal   ReadQx 

Tirzepatide Once Weekly for the Treatment of Obesity.

Pubmed   Journal   ReadQx 

Tirzepatide Once Weekly for the Treatment of Obesity.

Pubmed   Journal   ReadQx 

Tirzepatide Once Weekly for the Treatment of Obesity. Reply.

Pubmed   Journal   ReadQx 

Work Hours and Depression in U.S. First-Year Physicians.

Pubmed   Journal   ReadQx